Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study.
J Intern Med
; 268(2): 133-44, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20210842
ABSTRACT
OBJECTIVE:
Later life weight change and mortality amongst elders.DESIGN:
Nested case-control study.SETTING:
Six countries from the European Investigation into Cancer and nutrition-Elderly, Network on Ageing and Health.SUBJECTS:
A total of 1712 deceased (cases) and 4942 alive (controls) were selected from 34,239 participants, > or = 60 years at enrolment (1992-2000) who were followed-up until March 2007. Annual weight change was estimated as the weight difference from recruitment to the most distant from-date-of-death re-assessment, divided by the respective time. OUTCOMEMEASURES:
Mortality in relation to weight change was examined using conditional logistic regression.RESULTS:
Weight loss > 1 kg year(-1) was associated with statistically significant increased death risk (OR = 1.65; 95% CI 1.41-1.92) compared to minimal weight change (+/-1 kg year(-1)). Weight gain > 1 kg year(-1) was also associated with increased risk of death (OR = 1.15; 95% CI 0.98-1.37), but this was evident and statistically significant only amongst overweight/obese (OR = 1.55; 95% CI 1.17-2.05). In analyses by time interval since weight re-assessment, the association of mortality with weight loss was stronger for the interval proximal (< 1 year) to death (OR = 3.10; 95% CI 2.03-4.72). The association of mortality with weight gain was stronger at the interval of more than 3 years and statistically significant only amongst overweight/obese (OR = 1.58; 95% CI 1.07-2.33). Similar patterns were observed regarding death from circulatory diseases and cancer.CONCLUSIONS:
In elderly, stable body weight is a predictor of lower subsequent mortality. Weight loss is associated with increased mortality, particularly short-term, probably reflecting underlying nosology. Weight gain, especially amongst overweight/obese elders, is also associated with increased mortality, particularly longer term.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Mortalidade
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Grécia