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Reassortment of human rotavirus gene segments into G11 rotavirus strains.
Matthijnssens, Jelle; Rahman, Mustafizur; Ciarlet, Max; Zeller, Mark; Heylen, Elisabeth; Nakagomi, Toyoko; Uchida, Ryuichi; Hassan, Zahid; Azim, Tasnim; Nakagomi, Osamu; Van Ranst, Marc.
Afiliação
  • Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. jelle.matthijnssens@uz.kuleuven.be
Emerg Infect Dis ; 16(4): 625-30, 2010 Apr.
Article em En | MEDLINE | ID: mdl-20350376
G11 rotaviruses are believed to be of porcine origin. However, a limited number of G11 rotaviruses have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships of these strains, we analyzed the complete genomes of 2 human G11P[25] strains, 2 human G11P[8] strains, and 3 porcine reference strains. Most of the 11 gene segments of these 7 strains belonged to genotype 1 (Wa-like). However, phylogenetic clustering patterns suggested that an unknown G11P[25] strain with a new I12 VP6 genotype was transmitted to the human population, in which it acquired human genotype 1 gene segments through reassortment, resulting in a human G11P[8] rotavirus strain with an entire human Wa-genogroup backbone. This Wa-like backbone is believed to have caused the worldwide spread of human G9 and G12 rotaviruses. G11 human rotavirus strains should be monitored because they may also become major human pathogens.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vírus Reordenados / Rotavirus / Genes Virais Limite: Animals / Humans Idioma: En Revista: Emerg Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Bélgica

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Vírus Reordenados / Rotavirus / Genes Virais Limite: Animals / Humans Idioma: En Revista: Emerg Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Bélgica