Simultaneous QTL detection and genomic breeding value estimation using high density SNP chips.
BMC Proc
; 4 Suppl 1: S9, 2010 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-20380763
ABSTRACT
BACKGROUND:
The simulated dataset of the 13th QTL-MAS workshop was analysed to i) detect QTL and ii) predict breeding values for animals without phenotypic information. Several parameterisations considering all SNP simultaneously were applied using Gibbs sampling.RESULTS:
Fourteen QTL were detected at the different time points. Correlations between estimated breeding values were high between models, except when the model was used that assumed that all SNP effects came from one distribution. The model that used the selected 14 SNP found associated with QTL, gave close to unity correlations with the full parameterisations.CONCLUSIONS:
Nine out of 18 QTL were detected, however the six QTL for inflection point were missed. Models for genomic selection were indicated to be fairly robust, e.g. with respect to accuracy of estimated breeding values. Still, it is worthwhile to investigate the number QTL underlying the quantitative traits, before choosing the model used for genomic selection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
BMC Proc
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Holanda