Memory T-cell trafficking: new directions for busy commuters.
Immunology
; 130(2): 158-65, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20408895
ABSTRACT
The immune system is unique in representing a network of interacting cells of enormous complexity and yet being based on single cells travelling around the body. The development of effective and regulated immunity relies upon co-ordinated migration of each cellular component, which is regulated by diverse signals provided by the tissue. Co-ordinated migration is particularly relevant to the recirculation of primed T cells, which, while performing continuous immune surveillance, need to promptly localize to antigenic sites, reside for a time sufficient to carry out their effector function and then efficiently leave the tissue to avoid bystander damage. Recent advances that have helped to clarify a number of key molecular mechanisms underlying the complexity and efficiency of memory T-cell trafficking, including antigen-dependent T-cell trafficking, the regulation of T-cell motility by costimulatory molecules, T-cell migration out of target tissue and fugetaxis, are reviewed in this article.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Movimento Celular
/
Memória Imunológica
/
Vigilância Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunology
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido