Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry.
Org Lett
; 12(10): 2398-401, 2010 May 21.
Article
em En
| MEDLINE
| ID: mdl-20423109
ABSTRACT
A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biotina
/
Quelantes
/
Compostos Radiofarmacêuticos
/
Ciclo-Octanos
/
Compostos Heterocíclicos com 1 Anel
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos