Spectrum of HIV lymphoma 2009.
Curr Opin Hematol
; 17(4): 362-7, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20442655
ABSTRACT
PURPOSE OF REVIEW HIV-infected individuals remain at an increased risk for developing malignancies despite the use of combined antiretroviral therapy. Lymphomas comprise a large proportion of the malignancies that affect the HIV-infected population in developed countries. This review summarizes the recent progress made in HIV lymphoma research published in 2009 through January 2010. RECENT FINDINGS:
The majority of investigation in this field has been in diffuse large B-cell lymphoma, with infusional therapy remaining promising. Rituximab likely improves complete response and possibly overall survival, but may be associated with increased infections in a subset of patients with very low CD4 cell counts. Risk factors associated with the development of lymphoma include low CD4 cell count and likely cumulative HIV viremia. Biologic insights have been realized regarding pathogenesis.SUMMARY:
Overall, the outcome for HIV lymphoma continues to improve as insights into the pathophysiology and treatment advance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Linfoma Relacionado a AIDS
/
Terapia Antirretroviral de Alta Atividade
/
Transplante de Células-Tronco
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Hematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos