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[Prospective study on associations between levels of total cholesterol, triglyceride and risk of ischemic and hemorrhagic strokes].
Jiang, Bin; Fang, Xiang-hua; Liu, Yun-hai; Dai, Xiu-ying; Lin, Zhi-guo; Su, Fang-zhong; Yang, Qi-dong; Wang, Wen-zhi; Wu, Sheng-ping; Li, Shi-chuo.
Afiliação
  • Jiang B; Department of Neuroepidemiology, Beijing Neurosurgical Institute, Capital University of Medical Science, Beijing 100050, China. bjyjiang@hotmail.com
Zhonghua Xin Xue Guan Bing Za Zhi ; 38(3): 268-71, 2010 Mar.
Article em Zh | MEDLINE | ID: mdl-20450572
OBJECTIVE: To explore associations between levels of total cholesterol (TC), triglyceride (TG) and incidence of ischemic and hemorrhagic strokes in populations. METHODS: Baseline investigations on stroke-related risk factors and physical examinations were performed in 10 093 (> 35 years) stroke-free urban community residents from 5 cities in China during May to July in 1987, follow-up investigations on stroke events were made during 1998 to 2000. The hazard ratios and 95% confidence intervals (CI) of ischemic and hemorrhagic strokes in middle, high tertiles of baseline TC or TG levels were compared with low baseline tertile residents using the Cox regression model. RESULTS: There were 491 first strokes during the 8-years cohort follow-up. Compared with the low tertile, risk of ischemic stroke in the middle and high tertiles of TC level was increased by 61% (HR: 1.61, 95%CI: 1.14-2.27) and 58% (HR: 1.58, 95%CI: 1.12-2.22) after adjustments for DBP, age, sex and other variables in the Cox proportional hazards model. Compared with the low tertile, risk of ischemic stroke in the high tertile of TG level was increased by 43% (HR: 1.43, 95%CI: 1.02-2.00). However, risk of hemorrhagic stroke in the middle and high tertiles of TC level decreased by 12% (HR: 0.88, 95%CI: 0.64-1.22) and 33% (HR: 0.67, 95%CI: 0.48-0.95) compared with the low tertile. CONCLUSIONS: Elevated serum TC and TG are independent risk factors for risk of ischemic stroke. However, low TC was related with increased risk of hemorrhagic stroke.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Colesterol / Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: Zh Revista: Zhonghua Xin Xue Guan Bing Za Zhi Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Colesterol / Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: Zh Revista: Zhonghua Xin Xue Guan Bing Za Zhi Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China