Rapid access to morphinones: removal of 4, 5-ether bridge with Pd-catalyzed triflate reduction.
Tetrahedron Lett
; 51(17): 2359-2361, 2010 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-20495617
ABSTRACT
A new synthetic method for the removal of the 4, 5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2010
Tipo de documento:
Article