Your browser doesn't support javascript.
loading
[Association of single nucleotide polymorphisms of kallikrein 1 gene with cerebral hemorrhage in Changsha Han Chinese].
Zeng, Yi; Zhang, Le; Hu, Zhong-yang; Yang, Qi-dong; Liu, Bao-qiong; Ma, Ming-ming; Liu, Yun-hai; Xu, Hong-wei; Xia, Jian; Du, Xiao-ping; Hu, Zhi-ping.
Afiliação
  • Zeng Y; Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 27(3): 316-9, 2010 Jun.
Article em Zh | MEDLINE | ID: mdl-20533273
OBJECTIVE: To explore the association between single nucleotide polymorphisms (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han Chinese. METHODS: Two hundred and seventy-three cerebral hemorrhage (CH) patients and 140 healthy controls were collected. The SNPs of rs5516 and rs5517 loci of KLK1 gene were analyzed by SNaPshot methods and direct sequencing. RESULTS: (1)Genotype and allele frequencies in rs5516 locus had no difference between the CH patients and controls (P> 0.05). However, the A allele frequency of the rs5517 locus in CH patients was higher than that in the control group (0.419, 0.321 respectively, P< 0.05). (2)In the control group,the levels of diastolic blood pressure (DBP) of the GA and AA genotype carriers of the rs5517 locus were significantly higher than those of the GG genotype (P< 0.05), while the levels of blood pressure were not significantly different among different genotypes of the rs5516 polymorphism in both CH patients and the control group(P> 0.05). CONCLUSION: Author's preliminary results suggested that the rs5517 polymorphism was associated with cerebral hemorrhage, while the rs5516 polymorphism was not in Changsha Han Chinese.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Calicreínas Teciduais / Polimorfismo de Nucleotídeo Único Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Assunto da revista: GENETICA MEDICA Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Calicreínas Teciduais / Polimorfismo de Nucleotídeo Único Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Assunto da revista: GENETICA MEDICA Ano de publicação: 2010 Tipo de documento: Article