Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.
Cancer Res
; 51(13): 3559-67, 1991 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-2054792
ABSTRACT
Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model. Antitumor activity was studied using a tumor growth delay assay. Acute normal tissue toxicities (i.e., leukopenia and thrombocytopenia) and late normal tissue toxicities (i.e., myocardial and kidney injury) were evaluated by functional/physiological assays and by morphological techniques. Whole body hyperthermia (120 min at 41.5 degrees C) enhanced both Adriamycin-mediated antitumor activity and toxic side effects. The thermal enhancement ratio calculated for antitumor activity was 1.6. Thermal enhancement ratios estimated for "acute" hematological changes were 1.3, whereas those estimated for "late" damage (based on morphological cardiac and renal lesions) varied between 2.4 and 4.3. Thus, while whole body hyperthermia enhances Adriamycin-mediated antitumor effect, normal tissue toxicity is also increased, and the potential therapeutic gain of the combined modality treatment is eroded.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma Experimental
/
Doxorrubicina
/
Hipertermia Induzida
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1991
Tipo de documento:
Article