Subjective mild depressive symptoms are associated with abnormal diurnal cycle of salivary cortisol in older adults.
J Geriatr Psychiatry Neurol
; 24(1): 19-22, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-20558832
BACKGROUND: Alterations in cortisol secretion pattern seem to be involved in the associations between aging, depression, and cognitive decline. OBJECTIVE: The aim of this study was to mainly assess cortisol circadian profile in older adults with subjective depressive symptoms. METHODS: Salivary cortisol samples from healthy young (n = 22) and old adults (n = 22), and from older adults who self-reported depressive symptoms in Geriatric Depression Scale (n = 22) were collected at 7 AM, 4 PM, and 10 PM and were analyzed by radioimmunoassay. RESULTS: Older adults with depressive symptoms presented the characteristic cortisol circadian pattern, but they showed higher cortisol levels at 10 PM than healthy young and elderly controls. CONCLUSIONS: Our data suggest that mild depressive symptoms could be associated with a cortisol secretion pattern previously described as being predictive of cognitive decline.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
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Ritmo Circadiano
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Depressão
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Geriatr Psychiatry Neurol
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil