Early predictors of hypertension in prematurely born adolescents.
Acta Paediatr
; 99(12): 1812-8, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20586997
ABSTRACT
OBJECTIVE:
To assess the blood pressure of former preterm and term matched adolescent controls and to identify risk factors associated with blood pressure at 16 years.DESIGN:
Observational cohort study. Secondary analysis of a randomized clinical trial.SETTING:
Three academic centres participating in the Multicenter Indomethacin IVH Prevention Trial.PARTICIPANTS:
A total of 296 children born in 1989-1992 with birth weights 600 to <1250 g who participated in the Multicenter Indomethacin IVH Prevention Trial and 95 term controls were evaluated at 16 years. MAIN OUTCOMEMEASURES:
Blood pressure and predictors of blood pressure.RESULTS:
The adjusted mean difference in blood pressure for preterm adolescents was 5.1 mm Hg; p=0.002 for systolic and 2.1 mm Hg; p=0.027 for diastolic blood pressure. Among preterms, the primary predictors of increased systolic blood pressure were weight gain velocity between birth and 36 months (b=8.54, p<0.001), pre-eclampsia (b=5.67, p=0.020), non-white race (b=3.77, p=0.04) and male gender (b=5.09). Predictors of diastolic blood pressure were weight gain velocity between birth and 36 months (b=4.69, p=0.001), brain injury (b=6.51, p=0.002) and male gender (b=-2.4, p=0.02).CONCLUSIONS:
Early programming secondary to increased early weight gain velocity, intrauterine stress and neonatal brain injury may all contribute to risk of increased blood pressure among former preterm adolescents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Recém-Nascido de Peso Extremamente Baixo ao Nascer
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Pré-Hipertensão
/
Hipertensão
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos