Macromolecular and dendrimer-based magnetic resonance contrast agents.
Acta Radiol
; 51(7): 751-67, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20590365
ABSTRACT
Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Imageamento por Ressonância Magnética
/
Meios de Contraste
/
Substâncias Macromoleculares
/
Gadolínio
Limite:
Humans
Idioma:
En
Revista:
Acta Radiol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos