[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].

ABSTRACT

OBJECTIVE: To study the transformation of Astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus var. mongholicus. METHODS: The chemical components of pre and post-fermenting were comparatively analyzed by techniques of HPLC, column chromatography and spectral identification. Antioxidant effect of transformational product on vascular endothelial cells was researched. RESULTS: In fermenting of Astragalus membranaceus, Astragaloside IV was transformed into 6-O-beta-D-glucoside cycloastragenol, which had significant antioxidant effect. CONCLUSION: Biotransformation of Astragaloside IV in Astragalus membranaceus was occurred after bidirectional solid fermenting with Ganoderma lucidum, and the biotransformation could enhance effect.