Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.
Ann N Y Acad Sci
; 1202: 24-30, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20712768
ABSTRACT
beta-thalassemia is a disease associated with decreased beta-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Talassemia beta
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Modelos Animais de Doenças
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Eritropoese
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Ferro
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos