[HLA and sprue: a study of Sicilian families with celiac disease]. / HLA e celiachia: studio su alcune famiglie siciliane con malattia celiaca.
Pediatr Med Chir
; 12(4): 343-6, 1990.
Article
em It
| MEDLINE
| ID: mdl-2075098
ABSTRACT
The authors have studied the HLA genotypes in 17 Sicilian coeliac children, in their parents and in their healthy brothers. A positive association has been found between coeliac disease (C.D.) and HLA antigens; this was strongest firstly for DQW2 and than for DR7 and DR3. Those antigens however do not result specific for C.D., because they were present in healty-control population too and because one coeliac patient was DQW2, DR7 and DR3 negative. A distortion of vertical transmission of HLA haplotypes has been observed in the studied patients, and this occurred for DR3/DQW2 that was transmitted mainly by paternal way. Moreover, in the healty brothers of our coeliac subjects a significant reduction of HLA antigens DQW2, DR7 and DR3 has not been found. Those observation and the finding that in our families the responsible gene for C.D. seems to have a low penetrance, should induce to search others genetic markers for coeliac disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
/
Antígenos HLA
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Male
Idioma:
It
Revista:
Pediatr Med Chir
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Itália