Pulmonary thrombosis in the mouse following intravenous administration of quantum dot-labeled mesenchymal cells.
Nanotoxicology
; 4(1): 98-105, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20795905
ABSTRACT
Quantum dots (QDs) are emerging as novel diagnostic agents. Yet, only a few studies have examined the possible deleterious effects of QD-labeled stem cells. We assessed the potential toxic effects of QD-labeled human embryonic palatal mesenchymal (QD-HEPM) cells in male NOD/SCID mice for six months, following the administration of a single intravenous injection. Control animals were administered with non-labeled HEPM cells. No treatment-related clinical signs, hematological, or biochemical parameters were found in the QD-HEPM animals in comparison to control animals. Histologically, multifocal organizing thrombi were noted in the pulmonary arteries of all QD-HEPM animals from the one-week study group and in one animal from the one-month group. Additionally, increased severity of perivascular inflammation was noted at the injection sites of QD-HEPM animals from the one-week group. This is the first study reporting histopathological evidence for pro-thrombotic adverse effects mediated by QD labeling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
/
Transplante de Células
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Transplante de Células-Tronco Mesenquimais
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Pontos Quânticos
/
Células-Tronco Mesenquimais
Limite:
Animals
/
Humans
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Male
Idioma:
En
Revista:
Nanotoxicology
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Israel