Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation.
Bioorg Med Chem Lett
; 20(19): 5815-7, 2010 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-20800484
ABSTRACT
In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzamidinas
/
Antimaláricos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França