Gold(I)-catalyzed cyclization of ß-allenylhydrazones: an efficient synthesis of multisubstituted N-aminopyrroles.

ABSTRACT

The gold(I)-catalyzed cycloisomerization of ß-allenylhydrazones provides an efficient access to multisubstituted N-aminopyrroles, which are obtained in good to excellent yields. This new intramolecular cyclization method can be applied either to alkyl- or aryl-substituted allenes. The reaction proceeds under mild conditions with short reaction times through a selective intramolecular 1,2-alkyl or -aryl migration extending the general scope of the reaction.