Hypertension is the metabolic syndrome component most strongly associated with microvascular complications and coronary artery calcification in Type 1 diabetes.
J Endocrinol Invest
; 34(3): e58-63, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-20855932
ABSTRACT
AIM:
To evaluate the association of metabolic syndrome (MetS) and its individual components with microvascular complications and coronary artery calcification (CAC) in patients with Type 1 diabetes. MATERIAL/SUBJECTS ANDMETHODS:
Cross-sectional study included 261 patients with Type 1 diabetes. Patients were assessed regarding the presence of MetS according to National Cholesterol Education Program (NCEP) criteria. CAC score was measured in a subset of 100 patients without known cardiovascular disease.RESULTS:
The prevalence of MetS was 13.4% according to the NCEP criteria. Microvascular complications and CAC were more frequent in patients with MetS. In a multiple logistic regression analysis, MetS remained associated with nephropathy [OR 6.33 (95% CI 2.54-15.77), p<0.001], but not with retinopathy and CAC. Among the MetS components, hypertension was associated with presence of retinopathy [OR 4.04 (95% CI 1.65- 9.90), p=0.002], nephropathy [OR 5.92 (95% CI 2.42-14.4), p<0.001] and CAC [OR 2.97 (95% CI 1.06-8.30), p=0.03].CONCLUSIONS:
Hypertension was the only MetS component associated with retinopathy, nephropathy and the presence of CAC. Hypertension was better associated with CAC than MetS itself.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calcificação Fisiológica
/
Doenças Cardiovasculares
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Vasos Coronários
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Síndrome Metabólica
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Diabetes Mellitus Tipo 1
/
Hipertensão
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil