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Therapeutic plasma exchange a potential strategy for patients with advanced heart failure.
Torre-Amione, Guillermo; Orrego, Carlos M; Khalil, Nashwa; Kottner-Assad, Christian; Leveque, Christopher; Celis, Rene; Youker, Keith A; Estep, Jerry D.
Afiliação
  • Torre-Amione G; Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, Texas, USA. gtorre@tmhs.org
J Clin Apher ; 25(6): 323-30, 2010.
Article em En | MEDLINE | ID: mdl-20872844
ABSTRACT

BACKGROUND:

Previous reports had emphasized the importance of humoral immunity in heart failure in humans, primarily determined by the presence of circulating antibodies. However, there is little or no information about the frequency of anticardiac antibodies present in failing human myocardium.

METHODS:

Clinical data and myocardial tissue samples were analyzed to determine the role of humoral immunity in patients with chronic heart failure (CHF) in different SETTINGS.

RESULTS:

Anticardiac antibodies were found present in failing hearts but not in normal control hearts. Further, the level of expression of these anticardiac antibodies changed with the severity of the disease state; and in patients with acute heart failure, we found selective activation of B cells. Finally, treatment of CHF patients with therapeutic plasma exchange, a strategy that removes circulating antibodies, resulted in a reduction in anticardiac antibody deposition and improvements in cardiac function.

CONCLUSION:

These data collectively suggest a role of humoral immunity in the progression of heart failure.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Troca Plasmática / Insuficiência Cardíaca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Troca Plasmática / Insuficiência Cardíaca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos