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Expression of SM22α (transgelin) in glomerular and interstitial renal injury.
Inomata, Shigeru; Sakatsume, Minoru; Sakamaki, Yuichi; Wang, Xingzhi; Goto, Shin; Yamamoto, Tadashi; Gejyo, Fumitake; Narita, Ichiei.
Afiliação
  • Inomata S; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Nephron Exp Nephrol ; 117(4): e104-13, 2011.
Article em En | MEDLINE | ID: mdl-20924204
BACKGROUND/AIMS: SM22α, transgelin, is abundantly expressed in smooth muscle tissues and our previous work demonstrated that it is a novel marker of injured glomerular epithelial cells in rat antiglomerular basement membrane nephritis. In this study, we investigated SM22α expression in models of glomerular and interstitial renal injury. METHODS: The 5/6 nephrectomy (Nx) model, ischemia-reperfusion (I/R) model and puromycin aminonucleoside (PAN) nephrosis of rats were studied. Immunohistochemical analyses and immunoelectron microscopic studies of SM22α expression were performed. RESULTS: In the 5/6 Nx model, SM22α was first expressed in peritubular interstitial cells and was also expressed in injured glomerular epithelial cells at 8 weeks. In the I/R model, SM22α expression was induced in peritubular interstitial cells as early as 12 h after I/R with expression sustained at 7 days. However, SM22α was not detected in any glomerular cells or tubular epithelial cells. In PAN nephrosis, SM22α was only expressed in glomerular epithelial cells after 1 week, but expression was transient. CONCLUSION: SM22α was expressed in glomerular epithelial cells and interstitial cells in renal injury. SM22α is differentially upregulated in various models of renal injury and merits further study.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rim / Nefropatias / Glomérulos Renais / Proteínas dos Microfilamentos / Proteínas Musculares Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Nephron Exp Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rim / Nefropatias / Glomérulos Renais / Proteínas dos Microfilamentos / Proteínas Musculares Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Nephron Exp Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Japão