[Association of the ABCG1 gene polymorphism with the susceptibility and severity of coronary atherosclerotic disease].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 27(5): 506-11, 2010 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-20931526
ABSTRACT
OBJECTIVE:
To investigate the association of the ATP-binding cassette sub-family G member 1 (ABCG1) gene polymorphisms with coronary atherosclerotic disease (CAD) in Chinese Han population.METHODS:
A population based case-control association study was carried out in 541 patients with CAD and 649 healthy controls from Chinese Han population. Two single nucleotide polymorphisms (SNPs) of the ABCG1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression was used to compare the genotypic and allelic frequency difference.RESULTS:
The frequency of allele C of rs225374 was significantly higher in the CAD patients than that in the healthy controls (OR=1.186, 95%CI 1.009-1.394, P=0.039), while the difference was also significant in the male subgroup (OR=1.236, 95%CI 1.014-1.506, P=0.036). A statistically higher frequency of rs1044317 allele A was found in the CAD patients in comparison to the healthy controls (OR=1.187, 95%CI 1.009-1.397, P=0.039). In case-only association study, rs225374 showed significant association in the high Gensini score group compared with the low Gensini score group (OR=1.303, 95%CI 1.024-1.657, P=0.031).CONCLUSION:
The two SNPs of the ABCG1 gene might be associated with the susceptibility and severity of CAD in Chinese Han population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Transportadores de Cassetes de Ligação de ATP
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2010
Tipo de documento:
Article