Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis.
J Neuroimmunol
; 231(1-2): 86-91, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20951441
ABSTRACT
Anti-NMDA-receptor encephalitis is a severe, treatable and potentially reversible disorder presenting with memory deficits, psychiatric symptoms and seizures. Initially described in young patients with ovarian teratoma, the disease is meanwhile increasingly recognized also in women without tumours, in men and in children. The presence of anti-glutamate receptor (type NMDA) autoantibodies in serum or cerebrospinal fluid is specific for this novel and widely underdiagnosed disorder. Early recognition is crucial since prognosis largely depends on adequate immunotherapy and, in paraneoplastic cases, complete tumour removal. Indirect immunofluorescence using NMDA-type glutamate receptors recombinantly expressed in human cells is a highly competent method for diagnosing anti-NMDA-receptor encephalitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Índice de Gravidade de Doença
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Receptores de N-Metil-D-Aspartato
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Encefalite Límbica
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha