Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain.
Br J Anaesth
; 106(1): 112-8, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20952763
ABSTRACT
BACKGROUND:
The aim of this study was to assess any interaction between ondansetron and paracetamol on a model of post-fracture pain in mice.METHODS:
In protocol A, after fracture of the tibia, mice were assigned to four groups paracetamol 30 mg kg⻹, paracetamol 50 mg kg⻹, paracetamol 100 mg kg⻹, or a saline vehicle i.p. In protocol B, after fracture of the tibia, mice were randomized to receive either paracetamol (100 mg kg⻹) plus saline (vehicle), paracetamol (100 mg kg⻹) plus ondansetron (1 mg kg⻹), paracetamol (100 mg kg⻹) plus ondansetron (2 mg kg⻹), saline plus ondansetron (2 mg kg⻹), or saline plus saline i.p. Three tests were used to assess pain behaviour von Frey filament application, hot-plate test, and a subjective pain scale. Rescue analgesia with morphine was administered as necessary.RESULTS:
In protocol A, paracetamol (100 mg kg⻹)-treated animals had less mechanical nociception, thermal nociception, and a lower subjective pain scale rating, when compared with those receiving paracetamol at 30 or 50 mg kg⻹ or saline [ED50 paracetamol=46.3 (6.34) mg kg⻹]. No difference was found between paracetamol (30 mg kg⻹) and saline-treated animals. In protocol B, the mechanical withdrawal threshold, the thermal withdrawal latency, and the subjective pain scale were lower after injection of paracetamol (100 mg kg⻹)+saline, paracetamol (100 mg kg⻹)+ondansetron (1 mg kg⻹), and paracetamol (100 mg kg⻹)+ondansetron (2 mg kg⻹), whereas in mice receiving saline+ondansetron (2 mg kg⻹) or saline+saline, there was no difference.CONCLUSION:
We found that paracetamol 100 mg kg⻹ blocked the development of hyperalgesia and allodynia after fracture pain and ondansetron did not modify the antinociceptive effect of paracetamol in this model.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fraturas da Tíbia
/
Ondansetron
/
Analgésicos não Narcóticos
/
Hiperalgesia
/
Acetaminofen
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França