[Signal transduction in urothelial cancer: how exactly do we know the targets for targeted therapy?]. / Signaltransduktion im Urothelkarzinom : Wie genau kennen wir die Ziele für eine zielgerichtete Therapie?
Urologe A
; 49(11): 1401-5, 2010 Nov.
Article
em De
| MEDLINE
| ID: mdl-20959951
ABSTRACT
Targeted therapies have helped to improve the quality of life and prolong the survival of many cancer patients. This progress is based on the growing understanding of cellular signal transduction pathways and regulatory systems in human cancers. In urothelial carcinoma, a number of specific alterations have been identified. These include mutations in FGFR3, HRAS, and PIK3CA leading to overactivity of MAPK and Akt signaling pathways especially in papillary tumors. In comparison, the RB1 and p53 regulatory systems that act more directly on cell cycle control are more commonly compromised in invasive carcinomas. Nevertheless, targeted therapies have shown little efficacy in the treatment of urothelial carcinoma so far, owing presumably to our incomplete knowledge of molecular changes affecting signal transduction pathways in this cancer type. Target genes of cancer pathways are regulated by epigenetic mechanisms, which determine their inducibility. Elucidating these control mechanisms could therefore prove important for developing targeted therapies for urothelial carcinoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Biomarcadores Tumorais
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Neoplasias Urológicas
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Urotélio
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Modelos Biológicos
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Proteínas de Neoplasias
Limite:
Animals
/
Humans
Idioma:
De
Revista:
Urologe A
Ano de publicação:
2010
Tipo de documento:
Article