Population pharmacokinetic analysis of the active product of dipyrone.
Int J Clin Pharmacol Ther
; 48(12): 791-7, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21084034
ABSTRACT
OBJECTIVE:
Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied. STUDY DESIGN ANDSETTING:
153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel. INTERVENTION Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statisticalanalysis:
Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored.RESULTS:
The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age.CONCLUSION:
A population pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Dipirona
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Clin Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Israel