[Effects of finasteride on hematuria associated with benign prostatic hyperplasia: a meta-analysis].
Zhonghua Nan Ke Xue
; 16(8): 726-9, 2010 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-21090349
ABSTRACT
OBJECTIVE:
To systematically evaluate the effects of finasteride on hematuria associated with benign prostatic hyperplasia (BPH).METHODS:
We electronically searched MEDLINE (December 1966-April 2009), EMBASE (December 1974-April 2009), The Cochrane Library (Issue 1, 2009), CNKI (December 1994-April 2009), VIP (December 1989-April 2009) and CBM (December 1978-April 2009) , and handsearched several relevant journals as well. Randomized controlled trials were assessed with the methods recommended by the Cochrane Collaboration. The data were screened and systematically analyzed by at least two reviewers independently using the RevMan 5.0 software.RESULTS:
Compared with the placebo control group, the finasteride group showed a significantly decreased incidence of hematuria during the 12 months follow-up period (OR 0.11, 95% CI 0.06-0.21, P < 0.05).CONCLUSION:
Finasteride has desirable therapeutic and preventive effects on BPH-associated hematuria. More well-designed multicentered randomized controlled trials of large sample size are invited to provide further evidence for this conclusion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiperplasia Prostática
/
Finasterida
/
Hematúria
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China