Isolation, structural assignment, and total synthesis of barmumycin.
J Org Chem
; 75(24): 8508-15, 2010 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-21090754
ABSTRACT
Barmumycin was isolated from an extract of the marine actinomycete Streptomyces sp. BOSC-022A and found to be cytotoxic against various human tumor cell lines. On the basis of preliminary one- and two-dimensional (1)H and (13)C NMR spectra, the natural compound was initially assigned the structure of macrolactone-type compound 1, which was later prepared by two different routes. However, major spectroscopic differences between isolated barmumycin and 1 led to revision of the proposed structure as E-16. On the basis of the synthesis of this new compound, and subsequent spectroscopic comparison of it to an authentic sample of barmumycin, the structure of the natural compound was indeed confirmed as that of E-16.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Streptomyces
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Produtos Biológicos
/
Linhagem Celular Tumoral
/
Lactonas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha