Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle.
Am Heart J
; 160(5): 812-8, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-21095266
ABSTRACT
BACKGROUND:
Angiotensin II receptor blockers have been proven to be beneficial in left ventricular failure. In patients with a morphologic right ventricle supporting the systemic circulation, its efficacy has not yet been established.METHODS:
We designed a multicenter, prospective, randomized, double-blind, placebo-controlled trial studying the effect of valsartan in patients with a systemic right ventricle due to a congenitally or surgically corrected transposition of the great arteries. The primary end point is the change in right ventricular ejection fraction as measured by cardiovascular magnetic resonance or multidetector row cardiac computed tomography in case of pacemaker patients.CONCLUSION:
This large prospective, double-blind, randomized, placebo-controlled trial will establish the role of angiotensin II receptor blockers (valsartan) in the treatment of patients with a systemic right ventricle.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Tetrazóis
/
Valina
/
Função Ventricular Direita
/
Disfunção Ventricular Direita
/
Bloqueadores do Receptor Tipo 1 de Angiotensina II
/
Átrios do Coração
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am Heart J
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Holanda