Plasminogen activator activity of normal and retinoic acid-treated post-implantation embryos.
Biochem Pharmacol
; 39(10): 1545-8, 1990 May 15.
Article
em En
| MEDLINE
| ID: mdl-2110809
ABSTRACT
Urokinase-type plasminogen activator (uPA) has been implicated in cellular migration accompanying different biological phenomena including organogenesis. An increase in uPA activity was observed in mouse post-implantation embryos during the early organogenesis period. Since we have previously shown that all-trans retinoic acid (RA) prevented the induction of uPA in mouse peritoneal macrophages, we have now assessed whether teratogenic doses of this agent could also interfere with uPA activity in mouse embryo in vitro and in vivo. Post-implantation embryos (8.5 days) were incubated for up to 24 hr with micromolar concentration of RA resulting in the occurrence of malformations. No significant difference in uPA activity was found between control and treated embryos. Likewise, uPA activity was not altered in embryos explanted on day 9.5 from dams treated 24 hr before with a teratogenic dose of RA. This study indicates that the teratogenic activity of RA is not caused by an inhibition of the induction of uPA in embryos.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Ativadores de Plasminogênio
/
Ativador de Plasminogênio Tipo Uroquinase
/
Embrião de Mamíferos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Bélgica