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A compact time-resolved system for near infrared spectroscopy based on wavelength space multiplexing.
Re, Rebecca; Contini, Davide; Caffini, Matteo; Cubeddu, Rinaldo; Spinelli, Lorenzo; Torricelli, Alessandro.
Afiliação
  • Re R; Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy. rebecca.re@mail.polimi.it
Rev Sci Instrum ; 81(11): 113101, 2010 Nov.
Article em En | MEDLINE | ID: mdl-21133455
ABSTRACT
We designed and developed a compact dual-wavelength and dual-channel time-resolved system for near-infrared spectroscopy studies of muscle and brain. The system employs pulsed diode lasers as sources, compact photomultipliers, and time-correlated single photon counting boards for detection. To exploit the full temporal and dynamic range of the acquisition technique, we implemented an approach based on wavelength space multiplexing laser pulses at the two wavelengths are alternatively injected into the two channels by means of an optical 2×2 switch. In each detection line (i.e., in each temporal window), the distribution of photon time-of-flights at one wavelength is acquired. The proposed approach increases the signal-to-noise ratio and avoids wavelength cross-talk with respect to the typical approach based on time multiplexing. The instrument was characterized on tissue phantoms to assess its properties in terms of linearity, stability, noise, and reproducibility. Finally, it was successfully tested in preliminary in vivo measurements on muscle during standard cuff occlusion and on the brain during a motor cortex response due to hand movements.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrofotometria Infravermelho / Imagem Molecular Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Rev Sci Instrum Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrofotometria Infravermelho / Imagem Molecular Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Rev Sci Instrum Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Itália