B cells in renal transplantation: pathological aspects and therapeutic interventions.
Nephrol Dial Transplant
; 26(3): 767-74, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21139038
ABSTRACT
B cells are vital in renal transplantation. B2 cells are part of the adaptive immune system. Activated B cells mature into plasma cells or memory B cells their life spans can be prolonged by niches. B cells have a wide variety of functions antibody production, antigen presentation, cytokine production and shaping of the splenic architecture. These functions play a vital role in graft rejection, both T cell-mediated rejection and antibody-mediated rejection. Markers of B cell activity include intragraft B cell infiltration, C4d deposition and circulating donor-specific antibodies. Many therapeutic options target B cells or plasma cells. As greater understanding is gained of their appropriate use, and new agents are developed, we should see prolonged graft survival and reduced graft rejection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Transplante de Rim
/
Rejeição de Enxerto
/
Sobrevivência de Enxerto
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nephrol Dial Transplant
Assunto da revista:
NEFROLOGIA
/
TRANSPLANTE
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido