Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target.
Future Oncol
; 6(12): 1837-47, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21142858
ABSTRACT
The prognosis and clinical management of patients with cancer is commonly determined by traditional clinical and pathological factors. Nevertheless, patients may present with significantly different clinical outcomes despite similar clinicopathological features. This has prompted intense research to find biological markers that may closely reflect tumor biology and thereby clinical outcome. This article presents the current knowledge on the prognostic significance of p27 expression in cancer and its potential role as a target for future therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Inibidor de Quinase Dependente de Ciclina p27
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Israel