Appearance of a nonfunctional isozyme of hepatic glycogen synthase in late gestation.
Arch Biochem Biophys
; 281(1): 152-6, 1990 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-2116768
ABSTRACT
Glycogen levels, glycogen synthase activities, and glycogen synthase protein levels were determined in liver tissues obtained from 14- to 19-day-old fetal mice, newborn mice, and adult mice. The results of these experiments demonstrate a significant increase in the quantity of hepatic glycogen synthase beginning at Day 17 of gestation and reaching adult levels at birth. However, during the same time period, there is a dramatic decrease in total glycogen synthase activity suggesting that the accumulating glycogen synthase molecules are unable to transfer UDP-glucose to glycogen. These inversely coordinated changes in the quantity and activity of glycogen synthase are consistent with the suggestion that glycogen synthesis in the near-term fetal mouse is being maintained by preexisting enzyme, while accumulating enzyme molecules may represent a quiescent isozyme.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicogênio Sintase
/
Isoenzimas
/
Fígado
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Arch Biochem Biophys
Ano de publicação:
1990
Tipo de documento:
Article