[Significance of the secreted frizzled-related protein 2 expression in earlobe keloid].
Zhonghua Zheng Xing Wai Ke Za Zhi
; 26(5): 369-72, 2010 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-21174795
ABSTRACT
OBJECTIVE:
To investigate the expression and the role of secreted frizzled-related protein 2 (SFRP2) in the earlobe keloid and find a valid way to treat the keloid with gene therapy.METHODS:
The expression of SFRP2 mRNA and protein was tested with in situ hybridization and Western Blot Analysis method in the different period of earlobe keloid.RESULTS:
The SFRP2 mRNA and protein expression at the keloid edge was significantly high in 12 month group than in 3 or 6 month groups (P < 0.01), but not than in 24 month group. The SFRP2 expression started to decrease in the keloid center 12 month later (P < 0.01). The SFRP2 expression was always higher in edge than in center during all the period (P < 0.05, P < 0.01).CONCLUSIONS:
The results suggest that SFRP2 may play an important role in the development of keloid, especially at the keloid edge. The high SFRP2 expression in endothelial cells and surrounding tissue is also important. It may be a new way for gene therapy of keloid by decreasing the SFRP2 expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orelha
/
Queloide
/
Proteínas de Membrana
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Zheng Xing Wai Ke Za Zhi
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China