Efficacy of prolonged valganciclovir therapy for congenital cytomegalovirus infection.
J Infect Chemother
; 17(4): 538-40, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21229284
ABSTRACT
We report prolonged valganciclovir (VGCV) treatment of a symptomatic cytomegalovirus infection case. Automated auditory brainstem evoked response performed at 5 days of age revealed severe hearing impairment. Cranial magnetic resonance (MR) imaging at 11 days of age showed abnormal findings. At 5 weeks of age, VGCV was started. The viral load in blood cells, plasma, and urine decreased during the 6-week treatment. Because of improvement of hearing level and no adverse effects, VGCV was restarted for an additional 6 weeks. Neither the patient's hearing impairment nor results of cranial MR imaging have become worse in 6 months. It is crucial to gather information from as many cases as possible treated with VGCV to establish a standard protocol for VGCV treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ganciclovir
/
Infecções por Citomegalovirus
/
Doenças do Recém-Nascido
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Infect Chemother
Assunto da revista:
MICROBIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão