Microstructural and functional connectivity in the developing preterm brain.
Semin Perinatol
; 35(1): 34-43, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21255705
ABSTRACT
Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Because variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared with term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Encefalopatias
/
Recém-Nascido Prematuro
/
Nascimento Prematuro
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Revista:
Semin Perinatol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos