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Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in Brazilian neonates.
Junqueira, Ana Luiza N; Tavares, Viviane R; Martins, Regina M B; Frauzino, Kamilla V; Silva, Agabo M da Costa e; Rodrigues, Izolina M X; Minamisava, Ruth; Teles, Sheila A.
Afiliação
  • Junqueira AL; Faculdade de Enfermagem, Universidade Federal de Goiás, Rua 227 quadra 68, 74605-080 Goiânia, GO, Brasil.
Mem Inst Oswaldo Cruz ; 106(1): 113-6, 2011 Feb.
Article em En | MEDLINE | ID: mdl-21340365
Recently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants' immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated (n = 221). All newborn infants received three intramuscular doses (10 µg) of HBV vaccine (Butang®) at 0,1 and six months. The first dose was administered at the maternity hospital within 12 h of birth. The geometric mean titres of anti-HBs were not different among newborn infants born to mothers who were anti-HBs-negative (492.7 mIU/mL) and anti-HBs-positive (578.7 mIU/mL) (p = 0.38). Eight infants did not respond to the HBV vaccine. Of them, six were born to anti-HBs-negative mothers and two were born to mothers with anti-HBs titres less than 50 mlU/mL. Despite the mother's anti-HBs-positive status, our data show a good immunogenicity of the Brazilian HBV recombinant vaccine in neonates.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Vacinas contra Hepatite B / Hepatite B / Anticorpos Anti-Hepatite B / Antígenos de Superfície da Hepatite B Limite: Adult / Humans / Male / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Vacinas contra Hepatite B / Hepatite B / Anticorpos Anti-Hepatite B / Antígenos de Superfície da Hepatite B Limite: Adult / Humans / Male / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Brasil