[Therapeutic effect of pelvic methotrexate injection via the posterior fornix for treatment of tubal pregnancy].

ABSTRACT

OBJECTIVE: To evaluate the therapeutic effect and safety of pelvic methotrexate (MTX) injection via the posterior fornix for treatment of tubal pregnancy. METHODS: Ninety-six patients with tubal pregnancy (mean age 21-40 years) were randomized into 3 groups for treatment with pelvic MTX injection via the posterior fornix+mifepristone+traditional Chinese medicine (experiment group), intramuscular MTX injection+mifepristone+traditional Chinese medicine (control group I), or mifepristone+traditional Chinese medicine (control group II). On days 4 and 7 of the treatment, blood ß-HCG of the patients in different groups was detected, and in cases with continuous reduction of blood ß-HCG or a reduction by over 15%, ß-HCG was checked every week. One week after the treatment, the size of the mass was measured by B-mode ultrasound. The clearance time of ß-HCG and the hospital stay of the patients were recorded. RESULTS: Twenty-nine patients in the experimental group were treated successfully, with a cure rate of 90.6%, which was significantly higher than those in the two control groups (P<0.05). The clearance time of ß-HCG and hospital stay were also much shorter in the experimental group (P<0.05). CONCLUSION: Pelvic MTX injection via the posterior fornix is a convenient procedure associated with minimal complications and serves as a good alternative for treatment of tubal pregnancy.