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Lack of relationship between acoustic startle and cognitive variables in schizophrenia and control subjects.
Hasenkamp, Wendy; Kelley, Mary; Egan, Glenn; Green, Amanda; Wilcox, Lisette; Boshoven, William; Lewison, Barbara; Duncan, Erica.
Afiliação
  • Hasenkamp W; Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA. wendy.hasenkamp@va.gov
Psychiatry Res ; 187(3): 324-8, 2011 May 30.
Article em En | MEDLINE | ID: mdl-21397338
Measures of acoustic startle such as prepulse inhibition (PPI) and startle latency have been found to be impaired in schizophrenia, and are commonly thought to be related to cognitive deficits in this disease. However, findings about the relationship between startle variables and cognitive performance have been equivocal. In this study, we examined correlations between startle measures (baseline startle magnitude, latency, habituation and PPI) and cognitive performance (using the Benton Visual Retention Test, Conner's Continuous Performance Test, California Verbal Learning Test, Finger Tapping Test, and Wisconsin Card Sort Test) in 107 schizophrenia patients and 94 healthy controls. Overall, there was a lack of any significant relationship between these constructs in both populations when correcting for multiple comparisons. This suggests that alterations in startle measures seen in schizophrenia may not reflect elements of information processing that cause cognitive deficits in the disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Reflexo de Sobressalto / Transtornos Cognitivos Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Reflexo de Sobressalto / Transtornos Cognitivos Tipo de estudo: Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos