Your browser doesn't support javascript.
loading
Application of interferon response-related gene array to the antiviral treatment outcome in chronic hepatitis C.
Xing, Tong-Jing; Xv, Hong-Tao; Zhao, Wei; Shen, Ling; Li, Hao; Cai, Ren-Tian.
Afiliação
  • Xing TJ; Department Infectious Diseases, Taizhou People's Hospital, Taizhou 225300, China. xingtj518@sina.com.cn
Hepatogastroenterology ; 57(102-103): 1257-63, 2010.
Article em En | MEDLINE | ID: mdl-21410068
BACKGROUND/AIMS: It has been known that viral factors such as genotype and viral load have a major influence on the outcome of antiviral treatment. Nevertheless, researchers have become increasingly aware that host genetic factors can modulate the response to antiviral treatment. The underlying mechanisms for the varying virologic response rates to IFNalpha-based antiviral therapy are unknown. METHODOLOGY: RNA was isolated from peripheral blood monocytes from treatment-naïve patients with chronic hepatitis C before and at the end of treatment. Gene expression was measured using SuperArray microarrays and compared to that of healthy controls. RESULTS: Ten patients were classified as rapid responders (RRs) and seven patients as non-RRs according to the serum HCV RNA level after 4 weeks of treatment in 17 patients with CHC. Compared with healthy controls, nine and eighteen different expression genes were found significantly in patients with RR and N-RR, respectively. Five different expression genes were found between the patients with RR and N-RR. Two genes that were down-regulated were found between HCV genotype 1b and genotype 2a. Seven different expression genes that were all down-regulated were found between the patients with ETVR and N-ETVR. CONCLUSIONS: (1) The down-regulation of some IFN response-related genes are associated with null response to treat with interferon. (2) It should be HCV genotype 1b is more successful in inducing the down-regulation of IFN response-related genes than HCV genotype 2a, thus contribute to the resistance to IFN.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Polietilenoglicóis / Ribavirina / Interferon-alfa / Hepatite C Crônica Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hepatogastroenterology Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Polietilenoglicóis / Ribavirina / Interferon-alfa / Hepatite C Crônica Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Hepatogastroenterology Ano de publicação: 2010 Tipo de documento: Article País de afiliação: China