Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.
Ann Neurol
; 69(3): 445-54, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21446020
ABSTRACT
OBJECTIVE:
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system. Although the clinical impact of gray matter pathology in MS brains is unknown, 30 to 40% of MS patients demonstrate memory impairment. The molecular basis of this memory dysfunction has not yet been investigated in MS patients.METHODS:
To investigate possible mechanisms of memory impairment in MS patients, we compared morphological and molecular changes in myelinated and demyelinated hippocampi from postmortem MS brains.RESULTS:
Demyelinated hippocampi had minimal neuronal loss but significant decreases in synaptic density. Neuronal proteins essential for axonal transport, synaptic plasticity, glutamate neurotransmission, glutamate homeostasis, and memory/learning were significantly decreased in demyelinated hippocampi, but not in demyelinated motor cortices from MS brains.INTERPRETATION:
Collectively, these data support hippocampal demyelination as a cause of synaptic alterations in MS patients and establish that the neuronal genes regulated by myelination reflect specific functions of neuronal subpopulations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Sinapses
/
Hipocampo
/
Esclerose Múltipla
/
Bainha de Mielina
/
Fibras Nervosas Mielinizadas
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos