Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome.
Sleep Breath
; 16(2): 405-12, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-21448783
ABSTRACT
OBJECTIVES:
The aim of this study was to assess serum tumor necrosis factor alpha (TNFA) concentrations 8 months of continuous positive airway pressure (CPAP) therapy.DESIGN:
This study used prospective, observational clinical trial. PATIENTS Sixty-six patients with newly diagnosed sleep apnea syndrome (12 women, 54 men), age 52.3 ± 9.8 (mean ± SD) with a body mass index of 29.7 ± 4.4 and an apnea-hypopnea index of 39.7 ± 26.8, were studied. INTERVENTION CPAP was administered for a mean of 7.8 ± 1.3 months. MEASUREMENTS ANDRESULTS:
TNFA concentrations using an ultrasensitive ELISA assay at baseline and follow-up. TNFA decreased in men with high (5.2 ± 1.7 h/night, -0.46 ± 1.1 ng/l, p = 0.001) and with low (2.5 ± 1.0 h/night -0.63 ± 0.77 ng/l, p = 0.001) adherence but not in women. Average number of hours of CPAP use correlated positively with delta TNFA (R (2) 0.08, p = 0.04)CONCLUSION:
Long-term CPAP positively affects TNFA even in men with poor adherence to CPAP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Fator de Necrose Tumoral alfa
/
Apneia Obstrutiva do Sono
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Pressão Positiva Contínua nas Vias Aéreas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Sleep Breath
Assunto da revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Suíça