Clinical features of nine patients with alternating hemiplegia of childhood.
J Paediatr Child Health
; 47(10): 734-6, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21449903
ABSTRACT
AIM:
To define clinical features of patients with alternating hemiplegia of childhood.METHODS:
We retrospectively reviewed the clinical presentation and course of the disease in patients diagnosed between January 2003 and December 2008 at the Pediatric Neurology Department of the Istanbul Medical Faculty.RESULTS:
The nine patients had a mean age of 6.6 months (2-15 months) at the onset of symptoms. Paroxysmal eye movements were the early symptom of five patients. All patients had recurrent alternating hemiplegic episodes and relief of symptoms while sleeping. Duration of events varied widely from few minutes to several days and was associated with slowly progressive neurological deterioration. Flunarizine might decrease frequency of events but is not effective to neurological deterioration. Amantadine as an alternative agent is used in add-on therapy, but epileptogenic side effect prevented the evaluation of long-term efficacy.CONCLUSION:
Trials on new agents like amantadine are necessary for more effective control of the disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemiplegia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Paediatr Child Health
Assunto da revista:
PEDIATRIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Turquia