Selective and multiple functionalization of pyridines and alkaloids via Mg- and Zn-organometallic intermediates.
Org Lett
; 13(9): 2306-9, 2011 May 06.
Article
em En
| MEDLINE
| ID: mdl-21462960
ABSTRACT
Quinine, nicotine, and related electron-rich amino-substituted pyridines were readily metalated using LiCl-solubilized TMP (2,2,6,6-tetramethylpiperidyl) bases in the presence of BF(3)·OEt(2). A full pyridine functionalization of all five positions of the pyridine ring can be realized by using an appropriate combination of TMP bases in the presence or absence of BF(3)·OEt(2).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Piridinas
/
Zinco
/
Alcaloides
/
Magnésio
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha