IL4I1: an inhibitor of the CD8⺠antitumor T-cell response in vivo.
Eur J Immunol
; 41(6): 1629-38, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21469114
ABSTRACT
The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H(2) O(2) production, and is highly expressed in tumor-associated macrophages. IL4I1 is also detected by immunohistochemistry in neoplastic cells from several B-cell lymphomas and some non-lymphoid tumors. To evaluate IL4I1's effect on tumor growth, we developed a mouse melanoma model constitutively coexpressing IL4I1 and the GP33 epitope. After GP33 vaccination, tumors developed more frequently in mice injected with IL4I1-expressing cells in comparison with mice receiving control cells. Tumor escape was preceded by a rapid diminution of IFN-γ-producing cytotoxic antitumor CD8(+) T cells. Moreover, tumor incidence was already increased when only 20% of the injected cells expressed IL4I1. The minimal IL4I1 activities leading to tumor escape were close to those detected in human melanoma and mesothelioma. Thus, we demonstrate the immunosuppressive functions of IL4I1 in vivo and suggest that IL4I1 facilitates human tumor growth by inhibiting the CD8(+) antitumor T-cell response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon gama
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Linfócitos T CD8-Positivos
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Evasão Tumoral
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Aminoácido Oxirredutases
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Neoplasias Experimentais
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França