Phosphine-catalyzed ß'-umpolung addition of nucleophiles to activated α-alkyl allenes.
Org Lett
; 13(10): 2586-9, 2011 May 20.
Article
em En
| MEDLINE
| ID: mdl-21491870
ABSTRACT
Highly functionalized alkenes can be prepared through phosphine-catalyzed ß'-umpolung additions of nucleophiles (carbon-, oxygen-, nitrogen-, and sulfur-centered) to activated α-disubstituted allenes, providing many potentially useful synthetic intermediates in good to excellent yields, often with high levels of stereoselectivity for the product olefin geometry. Various substitution patterns around the allene are compatible with the process, showcasing the synthetic utility of allenes under the conditions of nucleophilic phosphine catalysis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfinas
/
Alcenos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos