Human and rodent fibroblasts - model systems for studying senescence and immortalization (review).
Int J Oncol
; 1(2): 209-13, 1992 Jul.
Article
em En
| MEDLINE
| ID: mdl-21584533
ABSTRACT
Normal mammalian fibroblasts cultured in vitro will not divide indefinitely but undergo senescence and give rise to cells that can no longer be induced to divide. It is possible to overcome this finite life span by either cellular mutation or by the exogenous introduction of some viral or cellular oncogenes. This review describes the characteristics of senescence and the different ways in which it can be overcome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Int J Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Reino Unido