Keeping mRNPs in check during assembly and nuclear export.
Nat Rev Mol Cell Biol
; 12(6): 377-84, 2011 06.
Article
em En
| MEDLINE
| ID: mdl-21602906
ABSTRACT
The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process that is regulated in a spatial and temporal manner. Recent studies suggest that post-translational modifications play a part in coordinating the co-transcriptional assembly, remodelling and export of mRNP complexes through nuclear pores, adding a new level of regulation to the process of gene expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Núcleo Celular
/
Transporte Ativo do Núcleo Celular
/
Proteínas de Transporte Nucleocitoplasmático
/
Proteínas Associadas à Matriz Nuclear
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suíça